What is Multiple Sclerosis?
Multiple Sclerosis (MS, disseminated encephalomyelitis) is a chronic inflammatory autoimmune disease of the central nervous system (CNS; brain and spinal cord). Over two million people worldwide are affected, and the exact cause has not yet been conclusively determined. The disease is characterized by focal inflammatory episodes in the CNS that are either episodic or progressive, damaging nerve structures and causing scarring over time. At the damaged sites, the transmission of nerve impulses is disrupted, leading to a variety of symptoms. Women are about three times more likely to be affected than men. MS can occur at any age, but the most common onset is between the ages of 20 and 40.

What symptoms occur with Multiple Sclerosis?
The symptoms of MS vary greatly depending on the locations in the CNS where inflammation occurs, leading to diverse impairments in all regions of the body. Often, vision impairments due to inflammation of the optic nerve and skin sensory disturbances occur initially. Other common symptoms include disturbances in eye movement, pronounced fatigue, numbness and abnormal skin sensations (tingling, pins and needles), spastic paralysis, coordination difficulties, bladder and bowel dysfunction, sexual dysfunction, heat sensitivity, and concentration and memory disorders.
What is the course of the disease?
Despite all research efforts, the causes of MS have not yet been conclusively determined. It is important, however, that apparently the body’s own immune cells attack the nerve cell extensions. This leads to many small inflammations in the spinal cord and brain.
These small inflammations are referred to as demyelination foci, which can occur throughout the central nervous system. The inflammations can thus be referred to as causes, but it is not yet clear why the immune cells initially attack the nerves.
How is Multiple Sclerosis treated?
A cure for MS is not yet possible. However, various medications help to mitigate the course of the disease and delay the progression of physical disability. In acute relapse therapy, high-dose glucocorticoids (cortisone) are used. To reduce the frequency of relapses and slow the progression of the disease, various active substances that affect the immune system of those affected are used. Additionally, supplementary therapies that alleviate symptoms and enhance quality of life play an important role. These include antispasmodic drugs, endurance training, psychotherapy, occupational and physical therapy, and the provision of aids such as an orthosis.
What is the purpose of an orthosis?
Particularly movement restrictions, walking difficulties, and fear of falling are very stressful for affected individuals. In addition to regular physiotherapy, orthoses are often used in everyday life. They support walking and standing and help patients gain more autonomy and improve quality of life. An orthosis reduces the likelihood of falls and stumbling and contributes to improving the sense of security for people with MS. Furthermore, a properly fitted orthosis helps to avoid incorrect gait patterns, thus preventing potential posture damage. For an orthosis to be worn regularly and customer satisfaction to be ensured, detailed individual consultation and professional fitting are crucial.
How is an orthosis fitted?
Initially, determining the strength levels of the legs is important for fitting an orthosis. The individual muscle groups are examined more closely in a function test. The focus is on the leg that is to be supported and is accordingly weaker. For each muscle group, the degree of existing paralysis is indicated on a scale from 0 to 5. At strength level 0/5, there is complete paralysis of the respective muscle group, while at 5/5, function is completely preserved. Depending on the severity, the orthosis is individually adjusted.
Additionally, a standard walking test (6-minute walk test) is used to identify the degree of fatigue under stress. Function tests of the muscles are performed before and after walking over a period of six minutes. This allows the strength level of the muscle groups in the fatigued state to be determined and the orthosis to be precisely adapted to the individual needs.
Conclusion: More safety in everyday life despite MS thanks to an orthosis
Multiple Sclerosis presents daily challenges to those affected. An individually adapted orthosis helps to increase safety in everyday activities such as walking and standing, thereby preserving a degree of independence. Factors such as the achieved strength levels and the fatigue of the muscles play a crucial role in the adaptation and are assessed in detailed consultation sessions.
(Bishop and Rumrill, 2015) (Walton et al., 2020) (Baird et al., 2018) (Neuman et al., 2021) (A et al., 2020) (Stevens et al., 2013) (Swinnen et al., 2018) (Swinnen and Kerckhofs, 2015) (Swinnen et al., 2015) (Cederberg et al., 2019)
Literature
[1] A, K.H., Gh, A., M, A., M, B., Z, S., A, B., M, K., 2020. Design and Preliminary Evaluation of a New Ankle Foot Orthosis on Kinetics and Kinematics parameters for Multiple Sclerosis Patients. J Biomed Phys Eng 10, 783–792. https://doi.org/10.31661/jbpe.v0i0.2007-1136
[2] Agarwala, P., Salzman, S.H., 2020. Six-Minute Walk Test: Clinical Role, Technique, Coding, and Reimbursement. Chest 157, 603–611. https://doi.org/10.1016/j.chest.2019.10.014
[3] Baird, J.F., Sandroff, B.M., Motl, R.W., 2018. Therapies for mobility disability in persons with multiple sclerosis. Expert Rev Neurother 18, 493–502. https://doi.org/10.1080/14737175.2018.1478289
[4] Bishop, M., Rumrill, P.D., 2015. Multiple sclerosis: Etiology, symptoms, incidence and prevalence, and implications for community living and employment. Work 52, 725–734. https://doi.org/10.3233/WOR-152200
[5] Cederberg, K.L.J., Sikes, E.M., Bartolucci, A.A., Motl, R.W., 2019. Walking endurance in multiple sclerosis: Meta-analysis of six-minute walk test performance. Gait Posture 73, 147–153. https://doi.org/10.1016/j.gaitpost.2019.07.125
[6] Neuman, R.M., Shearin, S.M., McCain, K.J., Fey, N.P., 2021. Biomechanical analysis of an unpowered hip flexion orthosis on individuals with and without multiple sclerosis. J Neuroeng Rehabil 18, 104. https://doi.org/10.1186/s12984-021-00891-7
[7] Stevens, V., Goodman, K., Rough, K., Kraft, G.H., 2013. Gait impairment and optimizing mobility in multiple sclerosis. Phys Med Rehabil Clin N Am 24, 573–592. https://doi.org/10.1016/j.pmr.2013.07.002
[8] Swinnen, E., Christiaens, S., Ceulemans, L., Kerckhofs, E., 2015. Does wearing an orthotic device of the lower limb influence the quality of life of patients? A systematic review. Journal of Basic and Applied Research International 5, 1–13.
[9] Swinnen, E., Deliens, T., Dewulf, E., Van Overstraeten, S., Lefeber, N., Van Nieuwenhoven, J., Ilsbroukx, S., Kerckhofs, E., 2018. What is the opinion of patients with multiple sclerosis and their healthcare professionals about lower limb orthoses? A qualitative study using focus group discussions. NeuroRehabilitation 42, 81–92. https://doi.org/10.3233/NRE-172222
[10] Swinnen, E., Kerckhofs, E., 2015. Compliance of patients wearing an orthotic device or orthopedic shoes: A systematic review. J Bodyw Mov Ther 19, 759–770. https://doi.org/10.1016/j.jbmt.2015.06.008
[11] Walton, C., King, R., Rechtman, L., Kaye, W., Leray, E., Marrie, R.A., Robertson, N., La Rocca, N., Uitdehaag, B., van der Mei, I., Wallin, M., Helme, A., Angood Napier, C., Rijke, N., Baneke, P., 2020. Rising prevalence of multiple sclerosis worldwide: Insights from the Atlas of MS, third edition. Mult Scler 26, 1816–1821. https://doi.org/10.1177/1352458520970841
[12] Amboss – Multiple Sklerose
https://next.amboss.com/de/article/WR0PNf?q=Multiple+Sklerose#Zfc37457ca8f0aea91134b8e6e325e935 (accessed on 13.06.2022)

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